Academic Organization







- Oncogenesis of HTLV-1
- Pathogenesis of adult T-cell leukemia
- Isolation of new pathogenic viruses
- Molecular epidemiology and Drug resistance of HIV
- Oncogenesis of KSHV




Masahiro FujiiProfessotDivision of Virology, Niigata University Graduate School of Medical and Dental Sciences
Masayasu OieAssistant ProfessorDivision of Virology, Niigata University Graduate School of Medical and Dental Sciences
Masaya HiguchiAssociate ProfessorDivision of Virology, Niigata University Graduate School of Medical and Dental Sciences
Masahiko TakahashiAssistant ProfessorDivision of Virology, Niigata University Graduate School of Medical and Dental Sciences







Ohashi M, Sakurai M, Higuchi M, Mori N, Fukushi M, Oie M, Coffey RJ, Yoshiura K, Tanaka Y, Uchiyama M, Hatanaka M, and Fujii M / Human T-cell Leukemia Virus Type 1 Tax Oncoprotein Induces and Interacts with a Multi-PDZ Domain Protein, MAGI-3 / Virology / 320 / 52 / 62 / 2004 /

Hirata A., Higuchi M., Niinuma A., Ohashi M., Fukushi M., Oie M., Akiyama T., Tanaka Y., Gejyo F., Fujii M / PDZ Domain-Binding Motif of Human T-cell Leukemia Virus Type 1 Tax Oncoprotein Augments the Transforming Activity in a Rat Fibroblast Cell Line / Virology / 318 / 327 / 336 / 2004 /

Shinohara H, Fukushi M, Higuchi M, Oie M, Hoshi O, Ushiki T, Hayashi J, Fujii M. / Chromosome binding site of latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus is essential for persistent episome maintenance and is functionally substituted by histone H1 / J.Virol. / 76 / 12917 / 12924 / 2002 /

Takahashi T., Higuchi M., Fukushi M., Oie M., Ito M., Fujii M. / Homotypic cell-cell adhesion induced by human T-cell leukemia virus type 1 Tax protein in T-cell lines / Virology / 302 / 132 / 143 / 2002 /

Mori N., Yamada Y., Ikeda S., Yamasaki Y., Tsukasaki K., Tanaka Y., Tomonaga M., Yamamoto N., Fujii M. / Bay 11-7082 inhibits transcription factor NF-kB and induces apoptosis of HTLV-I infected T-cell lines and primary adult T-cell leukemia cells / Blood / 100 / 1828 / 1834 / 2002 /

Endo K., Hirata A., Iwai K., Sakurai M., Fukushi M., Oie M., Higuchi M., Hall W.W., Gejyo F., Fujii M. / Human T-cell Leukemia Virus (HTLV) Type 2 Tax Protein Transforms a Rat Fibroblast Cell Line but Less Efficiently than HTLV-1 Tax / J. Virol. / 76 / 2648 / 2653 / 2002 /

Niinuma A, Higuchi M, Takahashi M, Oie M, Tanaka Y, Gejyo F, Tanaka N, Sugamura K, Xie L, Green PL, and Fujii M. / Aberrant Activation of the Interleukin 2 Autocrine Loop through Nuclear Factor of Activated T cells by Nonleukemogenic Human T-cell Leukemia Virus Type 2 but not Leukemogenic Type 1 Virus. / J.Virology / 79 / 11925 / 11934 / 2005 /

Tsubata C, Higuchi M, Takahashi M, Oie M, Tanaka Y, Gejyo F, Fujii M. / PDZ domain-binding motif of human T-cell leukemia virus type 1 Tax oncoprotein is essential for the interleukin 2 independent growth induction of a T-cell line / Retrovirology / 2 / / / 2005 /

Higuchi M, Fujii M / Distinct functions of HTLV-1 Tax1 from HTLV-2 Tax2 contribute key roles to viral pathogenesis / Retrovirology / 6 / 117 / / 2009 / Online Journal

Shoji T, Higuchi M, Kondo R, Takahashi M, Oie M, Tanaka Y, Aoyagi Y, Fujii M / Identification of a novel motif responsible for the distinctive transforming activity of human T-cell leukemia virus (HTLV) type 1 Tax1 protein from HTLV-2 Tax2 / Retrovirology / 6(1) / 83 / / 2009 / Online Journal






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